Finally, antibiotic dose adjustment based on serum concentration determination may be required, because changes in the pharmacodynamics and pharmacokinetics of antibiotics have been reported in neutropenic patients [38 40].
Another definition is only based on serum concentration thresholds without considering biological or clinical abnormalities [ 14].
Most of the cut offs to evaluate nutrient inadequacies are based on serum concentration and body storage that are necessary to a specific metabolic task.
31 In this study, vitamin D status was defined based on serum concentration of 25(OH D as: deficiency ≤27.5 nmol/L; insufficiency 27.5 ≤25(OH D <50 nmol/L; and sufficiency ≥50 nmol/L.
Finally, antibiotic dose adjustment based on serum concentration determination may be required, because changes in the pharmacodynamics and pharmacokinetics of antibiotics have been reported in neutropenic patients [ 38- 40].
We obtained two sets of estimates, one based on serum concentrations and one based on urine concentrations.
Second, the main measure of renal function in this study was estimated GFR based on serum concentrations of creatinine, and not on independently verified clearance of an exogenous test molecule.
In the United States, the Centers for Disease Control and Prevention CDCC), as part of the National Health and Nutrition Examination Survey (NHANES), provides information on PFC exposures among older children based on serum concentrations in a representative sample of the U.S. general population ≥ 12 years of age (Kato et al. 2011).
Based on serum concentrations, the predominant dibenzo- p-dioxin congeners were OCDD and 1,2,3,4,6,7,8-HpCDD (mean percents of 73.8% and 22.2%, respectively), while 1,2,3,7,8-PeCDD and 1,2,3,4,6,7,8-HpCDD were the predominant congeners based on mean TEQs (mean percents of 56.2% and 37.0%, respectively).
Treatment doses of γ-tocotrienol used in the present study are physiologically relevant based on serum concentrations of tocotrienols that were found to ranged between 2-4 μM in individuals given a single oral dose of mixed tocotrienols (300 mg) under fed or fasted conditions [ 32].
In addition, using prediction equations based on serum creatinine concentration can be problematic if creatinine concentrations are not at steady state (Payne, 1986; Perrone et al, 1992).
