Sentence examples for based on sequence variants from inspiring English sources

Here, we traced genetic variation (based on sequence variants in the internal transcribed spacer region, ITS) among seven geographically isolated populations of the ichthyosporean Caullerya mesnili, a common microparasite of the cladoceran Daphnia (here, the D. longispina hybrid complex).

Contact: [email protected] Exome sequencing has become an invaluably powerful tool in the identification of disease causing variants (Bamshad et al., 2011; Robinson et al., 2011) and the first patients are now already treated based on sequence variant information of their exomes (Worthey et al., 2011).

Based on sequence conservation, human variants can be tested by introducing homologous mutations in the yeast ortholog.

Furthermore, the Obp proteins were present also in less intense spots but their identification was based on sequence regions identical for all variants not allowing correct determination of the particular variant and they are not further discussed in this study.

Based on sequence comparison, two highly similar variants were classified as subtype GHV-1, whereas the third variant represents subtype GHV-2.

Eleven sequence variants (two in BRCA1 and nine in BRCA2) may be potentially damaging based on sequence conservation and Grantham score, and five sequence variants are unlikely to be clinically relevant.

Using a binning procedure, readDepth calls copy number variants based on sequence depth, and then invokes a circular binary segmentation algorithm to call segment boundaries.

Taken together, use of primer variants based on sequence variations of HML-2 loci significantly increases the number of amplifiable loci.

The readDepth uses a binning procedure to call copy number variants based on sequence depth and then call segment boundaries using a circular binary segmentation algorithm.

Due to the fact that the clustering is based on sequence information alone, not all splice variants per locus were grouped into the same cluster in some cases.

We removed variant calls based on sequence reads with multiple differences from the reference as well as at positions where more than a quarter of the reads in both isolates carried the variant call.