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(2013) use applied physics to quantitate the fitness of HIV-1 Gag based on sequence variability across the protein.
Based on sequence variability of the entire protein, fHbp has been divided into three variant groups or two sub-families.
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In assessing probabilities of possible point mutations in the DENV-2 genome, we put the highest confidence weights to the predictions that are based on sequence variabilities observed at the nucleotide level within identified DENV-2 genome sequences.
Large TR were classified based on sequence similarity, chromosome position, monomer length, array variability, and GC content; we identified four superfamilies, eight families, and 62 subfamilies - including 60 not previously described.
We concluded that the φ6 populations evolved under low multiplicity showed greater genetic variability than the high MOI populations, on average, based on sequence data representing ~10% of the viral genome.
So far, attempts at investigating the genetic variability of T. cancriformis have been hampered by its low genetic variability [ 31, 32], therefore our phylogeographic survey of T. cancriformis is based on sequence variation on over 1000 bp of mitochondrial DNA containing highly informative mitochondrial genes.
Our approach was based on sequence mining.
This variability is unlikely to be due to alignment bias because we obtained similar estimates using an alternative method of finding short repeat sequences based on sequence complexity.
The full genomic sequence of pathogens together with information on genomic variability (e.g., from high-throughput sequencing of a large number of strains) can be used to design prophylactic vaccines based on sequence data alone.
(2) Filtering Based on Sequence Similarity Rate.
and subtypes based on sequence similarity.
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