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However, there are no apparent tools that could efficiently handle large multiple networks, such as those necessary to group proteins using more than one similarity criterion (e.g. based on sequence, structure or function) (Fig. 1A).
These elements are recognized by the transporting machinery based on sequence, structure, or both, although it is often difficult to probe sequence and structural requirements independently.
Biozon computes and stores similarity relationships between proteins based on sequence, structure or expression profiles.
Splitting domains based on sequence, structure and evolutionary considerations may not be necessary for evaluation of all targets.
Clearly, it is possible to have a single probabilistic methodology for finding similarities based on sequence, structure or simultaneous sequence and structure.
By employing comparative genomics methods to identify SINE loci in domestic and exotic feliforms, two feliform-specific CanSINE subfamilies were defined based on sequence structure and taxonomic distribution.
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Based on sequence-structure alignment studies, we have folded the amino acid sequence of HuPON1 onto the sixfold β-propeller structure of squid diisopropylfluorophosphatase (DFPase).
Although they may vary only subtly but the variation is difficult to decipher or correlate just based on sequence-structure-function comparisons.
The results of our independent clustering approaches are as follows: (i) 18 structure motifs were identified based on sequence and structure alignments using LocARNA (Smith et al., 2010; Will et al., 2007, 2012).
This is a fascinating insight, based on sequence and structure analysis alone, and illustrates how careful sequence searches and information from structural genomics can suggest functions for uncharacterized proteins.
Scoring methods based on sequence and/or structure can predict interaction preferences in coiled-coil-mediated bZIP transcription factor dimerization.
More suggestions(15)
based on sequence selection
based on population structure
based on sequence solubility
based on sequence content
based on pdb structure
based on chemical structure
based on sequence analysis
based on sequence conservation
based on homojunction structure
based on file structure
based on sequence comparison
based on design structure
based on bone structure
based on tree structure
based on sequence divergence
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