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The taxonomy-based specificity we observed here based on sequence space depends upon the entire peptide sequence, but at the functional level, these peptides are recognized based on the interacting residue positions in the C-terminal insertion signal peptide.
The predictive power of the methods is below that of SVM and PSSM which is not surprising as the prediction score based on sequence space is obtained by averaging over many sequence distances, an operation in which information on a single position in a sequence is lost.
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We also extended our analysis to include an additional set of genomic sequences obtained by targeted gene space sequencing based on sequence capture (see Methods, for details).
Prediction of active-site residues based on sequence information alone is clearly affected by the quality of the sequence data, in particular, on the effective coverage and extent of the sequence space around the protein of interest.
Our approach was based on sequence mining.
This result was based on sequencing at four widely spaced and variable loci (UL55/UL144/UL146/UL09).
The following results are based on the space of sequences H. Theorem 3.1.
This paper investigates the mathematical framework of multiresolution analysis based on irregularly spaced knots sequence.
BLAST predicts clusters based on protein sequence, thus the prediction space is limited to sequence related proteins.
In this study, we used the J S and Euclidean distance measures, but other distances may be more suitable to estimate phylogenetic distances between DNA or protein sequences based on their spaced-word frequencies.
Patient distribution is based on available space only.
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