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Further distinctions between the C- subtypes are based on sequence signatures in the N-terminus.
Alignment-free methods based on sequence signatures are powerful for analyzing genomic data without using reference genomes.
We applied cluster analysis based on sequence signatures of the 13 human gut metagenome samples published by Kurokawa et al. [ 28].
Additional file 1: Table S5 gives the parsimony scores on the separation of these two groups by the clustering based on sequence signatures.
We applied the 14 dissimilarity measures based on sequence signatures (defined in Materials and Methods) with different k-tuple sizes k = 2--10 in this dataset to detect the group relationships of the 90 samples by clustering analysis.
Similar to the simulation studies, we used UPGMA to cluster the samples based on the dissimilarity matrix, as defined by different dissimilarity measures based on sequence signatures, and we assessed how well the resulting cluster tree revealed the underlying 3 groups by the parsimony test.
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Although the actual prediction algorithms and methods differ, all are based on sequence signature patterns.
These include the widely-used microarray as well as the more recently developed methods based on sequence tag abundances such as the Massively Parallel Signature Sequencing (MPSS) technology.
For functional annotation, the non-redundant UniProt database and protein signature database, InterPro, were searched to assign the predicted protein sequences based on sequence similarities.
The signature peptide was chosen and identified from the tryptic hydrolyzates of bovine lactoferrin by ultra high-performance liquid chromatography and quadrupole-time-of-flight tandem mass spectrometry based on sequence database search.
This is based on aa sequence signatures as opposed to size, as a phylogram of only the C-terminal 94 aa peptides of all eight proteins reveals the same pattern (data not shown).
More suggestions(17)
based on staff signatures
based on sequence networks
based on heptamer signatures
based on sequence alignments
based on group signatures
based on chromatin signatures
based on sequence homologies
based on genome signatures
based on expression signatures
based on sequence features
based on sample signatures
based on hash signatures
based on gene signatures
based on mRNA signatures
based on event signatures
based on sequence similarities
based on ring signatures
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