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This paper introduces a novel scheme to isolate candidate functional mini-modules from a random population of genomic fragments based on sequence properties.
To do this, nodes in sequence similarity networks were labelled based on sequence properties.
Thus, quantifying sequence characteristics may reveal some aspects of functional features (such as general class type) based on sequence properties.
We developed and tested a naive Bayesian classifier based on sequence properties of the genes and the molecular function and biological processes in which they are involved.
DGP assigns a probability score using a decision tree model based on sequence properties i.e. protein length, phylogenetic extent, degree of conservation and paralogy [ 18].
We have applied the naive Bayes model to identify human genes likely to be involved in the cancer process based on sequence properties and the molecular function and biological process in which the genes are involved (based on GO terms).
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While there are long-standing methods for ranking a set of genes based on their annotations [ 25], there has been limited work on rankings based on sequencing properties.
The resulting imperfect miRNA:miRNA* duplex is then unwound and one strand is selected as the mature miRNA, based on sequence thermodynamic properties [25], whereas the complementary passenger strand is usually subjected to degradation.
Based on sequence, biochemical properties and co-factor binding, both T. cruzi proteins share characteristics with class I fumarases, enzymes found in bacteria and some other protozoa but absent from humans, that possess class II isoforms instead.
As a potential method to improve our models, we examined the Che homologues in R. sphaeroides to see if it was possible to identify to which pathway a Che homologue would belong based on sequence level properties.
Disorder prediction based directly on sequence properties.
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