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Taxonomy-independent methods, however, extract features from contigs to infer bins based on sequence composition, abundance, marker genes, time series abundance profiles or any combination of them (Wu et al., 2014; Kang et al., 2015; Lin and Liao, 2016).
Further, the example of elongation factor suggests that prediction of secondary structures based on sequence composition and sequence similarity to a 'homologue' should be exercised with caution.
The fragments are then separated based on sequence composition using denaturing gradient gel electrophoresis (DGGE).
The read classification based on sequence composition relies on the intrinsic features of the reads.
To explore this possibility, we performed coding potential calculations based on sequence composition [ 27].
A: Coding potential calculation (CPC) and coding/non-coding classification based on sequence composition [ 27].
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One of the main questions in phylogenomic analyses based on sequence information is the composition of the data set used.
HGT detection has been pursued by phylogenetic methods, based on sequence alignment, and by composition-based methods that involve alignment-free features such as G + C content, synonymous codon usage (SCU) and the frequencies of overlapping short oligomers.
Moreover, slight variation in these parameters, or the use of analyses based on sequence information content and base composition (which also distinguish P- from R-segments) gave essentially similar results (not shown).
A set of predicted tryptic peptide sequences was selected based on sequence uniqueness, size, and amino acid composition (Picotti et al., 2013; Bauer et al., 2014).
Meanwhile, Bauer et al. [ 21] has developed another method, based on sequence window representations with amino acid composition, evolutionary information, relative solvent accessibility and secondary structure.
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