Sentence examples for based on sequence complementarity from inspiring English sources
Use of distinct overhangs enables directional ligation based on sequence complementarity of one overhang with another, and their sequence is constant based on their position in the order of ligated modules.
Shortly after the discovery of the RNAi mechanism, scientists devised various methods of delivering small interfering RNAs (siRNAs) capable of co-opting the endogenous RNAi machinery and suppressing target gene expression based on sequence complementarity.
The miRanda algorithm is based on sequence complementarity between the mature miRNA and its target site, binding energy for the miRNA-target duplex, and the evolutionary conservation of the target site sequence and position in aligned UTRs of homologous genes found in human, mouse and rat [41].
Although most researchers adopt oligo probe design programs based on sequence complementarity and in silico thermodynamic simulation of hybridization, very few have actually attempted to identify the optimal hybridization conditions [45] and/or the optimal probe from multiple ones designed for the same target gene [40], [41].
MiRNAs bind to their target genes based on sequence complementarity.
Potential off-target effects are predicted based on sequence complementarity regions between siRNAs and mRNAs.
We first compiled the genes regulated by CNV-miRNAs using the targets from TargetScan5.1 [ 32], which predicts miRNA targets based on sequence complementarities, sequence context information and binding energy.
We next evaluated the probability of these EC-genes being targeted by miRNAs using TargetScan5.1 [ 22] and PicTar (four-way) [ 23], which predict miRNA targets based on sequence complementarities, sequence context information, binding energy, and were regarded by previous surveys having high confidence [ 24].
Expression microarrays use probes targeting specific genes based on nucleotide sequence complementarity to quantitatively measure mRNA levels for tens of thousands of genes.
Based on the sequence complementarity, possible targets for silencing are transposable elements that use the tRNA 3'-ends as primers.
The mature miRNA with RISC will bind to and silence its target mRNA based on seed sequence complementarity, generally at the 3' UTR.
