Sentence examples for based on sequence alone from inspiring English sources
The designation of specific isoforms coding for inducible or constitutive expression patterns is a delicate issue, based on sequence alone.
For instance in TXNL2, Agilent and Affymetrix target disjoint transcripts based on sequence alone.
Δ6 desaturase sequences cluster with a ubiquitous class of Δ8 sphingolipid long-chain-base (LCB) desaturases [ 17] preventing their functional designation to either class based on sequence alone.
Gratifyingly, for all species where so far an orphaned Torsin has been found, we now also find a LAP1/LULL1 homolog (for many species, it is difficult to distinguish between LAP1 and LULL1 based on sequence alone).
Proteins resident at specific localization sites – for example, the periplasm and the extracellular space – can be similar to the point that differentiating the two based on sequence alone can be difficult.
(It is worth noting that analysis of net charge at pH 7.44 based on sequence alone gives a relative ranking that is exactly reversed from that determined by zeta potential, showing that structural factors impact the relative number of charged residues exposed at the surfaces of the proteins and highlighting the utility of the zeta potential data).
Binding motifs are not informative enough to distinguish functional sites from non-functional ones based on sequence content alone.
By contrast to other therapeutic approaches, the druggable universe is not limited with antisense technology as these inhibitors can be rationally designed based on sequence information alone.
The advances in sequencing techniques and the accumulation of many protein sequences without the purified protein challenge the development of computer algorithms to identify dominant T-cell epitopes based on sequence data alone.
Hence, it is difficult to reliably predict the properties of C2 domains based on sequence analyses alone, and the basis for functional differences among synaptotagmins is poorly understood.
These results indicate that there is no clear answer as to which template to use for homology model building based on sequence similarity alone.
