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These nodes were selected and defined based on separate meta-analyses of task-related fMRI studies.
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Three separate meta-analyses based on the results of these trials have concluded that there is a 3%5%% overall survival advantage of CAB versus ADT alone that is statistically significant when less effective steroidal AR antagonists such as cyproterone acetate are excluded from the analysis [ 27– 29].
For each selected outcome and exposure, separate meta-analyses were conducted based on most-adjusted and least-adjusted RRs.
If an article presented separate meta-analyses on more than one eligible biomarker or outcome or on participants with different clinical settings, these meta-analyses were kept separate.
After data abstraction, we conducted separate meta-analyses (comparison treatment was always placebo) based on the first RCT, the first 3 RCTs, 5 RCTs, 10 RCTs, 20 RCTs and 23 RCTs.
If an article presented separate meta-analyses on more than one eligible outcome or type of clinical setting, we assessed those separately.
This is done by conducting separate meta-analyses on the respective subgroups and plotting overall estimates for both.
Conducting separate meta-analyses on each of these strata makes clinical sense, particularly if there is a difference in the observed effect between the two routes.
Subgroup analyses involve separating trials into groups on the basis of some characteristic (e.g., intervention dose) and then performing separate meta-analyses for each group.
Results Based on 33 IPD meta-analyses and 177 eligible, matched clinical guidelines there was evidence that IPD meta-analyses were being under-utilised.
Separate meta-analyses were conducted according to study design and outcome domain, in keeping with meta-analytic conventions.
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