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If externally validated, this scoring system has the potential to aid clinicians in targeting empiric anti-MRSA therapy based on risk for MRSA infection.
Children were included in the studies based on risk for first-degree familial asthma history (i.e. positive or negative, PFH or NFH respectively) [ 14, 15].
In 2012, Madaras-Kelly et al. evaluated guideline-endorsed HCAP regimens by stratifying patients based on risk for MDR pathogens [ 27].
We collapsed the score into three strata based on risk for MRSA (score of 0 to 1 (low), 2 to 4 (moderate), ≥5 (high)).
The European HeartScore [ 24] is based on risk for patients between 40 and 65 years and requires separate input for each individual using charts or an online calculator, which was not practical in our large cohort.
The most frequently documented intervention to control the outbreak was to prioritize contacts based on risk for infection and progression to disease to ensure that the highest risk contacts were completely evaluated (14 outbreaks).
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Our calculations are based on risks for smokers and non-smokers.
Similarly, case-finding – assessment of a patient based on risks for, and/or clinical signs or symptoms of, exposure – is often called, in this literature, 'targeted screening' or 'risk-based inquiry'.
A number of evidence-based reviews and guidelines have concluded that the lack of evidence regarding the benefits, and potential harms and costs, of such screening on women's health and well-being favours a case-finding approach (assessment of a patient based on risks for, and/or clinical signs or symptoms of, exposure) [ 19- 21].
Various schemes for genetic screening based on risk factors for mutations have been proposed, which include screening for RET, SDHB, SDHD and VHL in case of abdominal paragangliomas [ 2, 3].
The 22 deaths we uncovered probably represent only a small fraction of human influenza-associated mortality in Thailand during 2004 2007 given the narrowly defined criteria for testing based on risk factors for H5N1.
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