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This led the NTP (2001) to state: Because of clear species and strain differences in sensitivity, animal model selection should be based on responsiveness to endocrine-active agents of concern (i.e., responsive to positive controls), not on convenience and familiarity.
Thus, most of the ARORs have intrinsic enhancer potential, although in most cases this potential is either not materialized or not detectable when the AROR is assessed in its native context based on responsiveness of adjacent genes in C4-2B cells (Figure 2 and see Discussion).
Third, defining predictive validity based on responsiveness to known drugs inevitably restricts the focus to mechanisms affected by those drugs.
Two major groups of delayed mutants have been categorized in flowering-time studies based on responsiveness to day length (Rédei, 1962; Koornneef et al., 1991).
There was limited opportunity for these professionals to meet face to face and hence their view of each other was based on responsiveness to referrals and communication.
Therefore, the eradication of cancer cells in ectopic environments requires an understanding of their resistance to anchorage dependence for growth and survival based on responsiveness of their normal counterparts.
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A fact that influences the interpretation of the results is, that the individual GH dose in the trial was selected based on GH responsiveness according to estimated/expected growth response and adapted so that the child would reach MPHSDS within 2 years, although limited by the set maximal GH dose of 100 μg/kg/d.
"We have been highly successful in this area based on our responsiveness and consistency of approach.
Here, we asked if these observations hold true for the stem-like cells in NB cells, which were purified based on their responsiveness to a Sox2 reporter.
Stem-like NB cells were purified based on their responsiveness to a Sox2 reporter, a strategy previously used for several different cancer models25,26,27,28,29,30.
The development of effective prevention strategies for breast, endometrial and ovarian cancers (CA), based on hormonal responsiveness, is a paramount opportunity in the care of women at risk for these malignancies.
More suggestions(18)
based on reactivity
based on readiness
based on openness
based on sensitivity
based on adaptation
based on relevance
based on adaptability
based on susceptibility
based on flexibility
based on appropriateness
based on response
based on tenderness
based on replies
based on religion
based on material
based on duty
based on need
based on cryptography
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com