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For the one-year decision tree, healthcare costs incurred in each treatment arm were based on resource used data from the PLATO trial [7],[8] and unit costs of those resources from data in Thailand (Additional file 1: TableS1) [16],[17].
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Costs were based on resource use data from a Dutch academic medical center and costing guidelines.
Inpatient costs were derived from official G-DRGs codes (German Diagnosis Related Groups) in 2010 which are calculated based on resource use in 2008 (see Table 5).
The most likely explanation for the result is assortative mating based on resource use, as we were unable to find any selection acting on heterozygotes.
The costs of making the CHW visits was based on resource use including both personnel time and vehicle-related expenses valued in 2004 Rand.
Cost estimates per clinical pathway were based on resource use data collected in PLATO, as previously described.
Economic analysis used the Incremental Cost Effectiveness Ratio (ICER), based on resource use per quality-adjusted life year (QALY), measured using the EQ-5D instrument.
This integrative factor was further used to compute niche characteristics and niche overlap statistics between species based on resource use and distribution.
The cost analysis undertaken was based on resource use estimates garnered from the interview transcripts and clinical experts, and is subject to the assumptions made for each model.
Cost analysis was based on resource use for medical care, social care, caregiver productivity losses, and informal caregiver time reported in the Resource Utilization in Dementia Lite instrument and a complementary questionnaire.
The costs of staff time required for administrative procedures following an NSI were based on resource use estimates from a Belgian macroeconomic study [ 31] and INAMI unit costs [ 26].
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