Sentence examples for based on resistance mutations from inspiring English sources
This supports structural models based on resistance mutations that suggest maribavir (19) interacts directly with the ATP-binding pocket.
City-specific resistance was based on resistance reported in GISP.
Performing surveillance based on high-resistance mutations alone may be insufficient.
A most interesting example of this approach was provided by a study on EGFR-based Gefitinib resistance, which demonstrated resistance based on mutations that were not clonal, but could be revealed by application of the 454 Sequencing System (454 Life Sciences, Branford, CT, USA; Thomas et al, 2005).
Such intrinsic mechanisms also facilitate the development of resistance through acquired mechanisms that are based on genetic mutations or drug resistance genes.
For two other strains of H. armigera with high levels of resistance to Cry1Ac based on cadherin mutations (540-fold for SCD-r1 and 140-fold for XJ-r15), the magnitude of cross-resistance was lower to each toxin (Yang et al. 2009; Zhang et al. 2012b).
The most frequently acquired resistance to flucytosine is based on point mutations in the FUR1 gene.
Conformation-sensitive UIC2 could identify different classes of drug modulators of P-glycoprotein and the molecular mechanism underlying their interactions based on mutations in the multidrug resistance gene (MDR1; ABCB1) which led to different conformations of the molecule [21], [22].
It is particularly useful for detection of resistance mechanisms based on mutations in ribosomal RNA.
This study was carried out based on the mutation analysis in P. falciparum chloroquine resistant transporter (pfcrt) and P. falciparum multidrug resistance 1 (pfmdr1) genes.
However, few models of resistance to oxaliplatin exist to provide a clear mechanistic understanding of how resistance is created in tumours, which initially respond to oxaliplatin (acquired resistance), an event that may be distinct from resistance based on a germline variation or a mutation that has already occurred in tumour cells (primary resistance).
