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Putin is implementing a "Fortress Russia" policy, which is based on repression at home and confrontation abroad.
As Prime Minister, he attempted to rule by creating a neo-conservative hegemony based on repression, racism, and a vitriolic anti-left stance.
As Prime Minister, he attempted to rule by creating a neo-conservative hegemony based on repression, racism and a vitriolic anti-left stance.
Out of all the possible gene circuits based on repression, the negative feedback loop is the simplest, consisting of a single gene component that downregulates its own production by binding to its promoter (Becksei & Serrano, 2000).
Therapeutic approaches based on repression of cyclin D gene have also been investigated (Tiedemann et al, 2008; Dong et al, 2010) and may be applicable to EOCs presenting aberrant CCND2 expression due to DNA-copy number gains.
Three of them were purely transcriptional regulation circuits, based on repression and accompanied by rigorous mathematical modelling (Becksei & Serrano, 2000; Elowitz & Leibler, 2000; Gardner et al., 2000), while the fourth engineered an entire enzyme synthesis pathway (Farmer & Liao, 2000).
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The inferred network shows an architecture based on reciprocal repression between gap genes that can stably pattern the embryo on a realistic geometry but requires complex regulations such as those involving the Hunchback monomer and dimers.
Strategies based on MYCN repression by siRNA may prove unsatisfactory: in fact, efficient inhibition of MYCN levels is hampered by the high levels of MYCN.
Characterization of these features could be easily followed by a novel technique based on differential repression of the green fluorescent protein expression (Chan et al., 2014).
Overall, the basic molecular mechanisms of the early response of Arabidopsis to NPs were based on transcriptional repression and had a common pattern regardless of the composition of the different NPs.
The circadian clock of Arabidopsis, a popular model organism for plants, is more complex than expected, with negative feedback loops based on the repression of gene expression having a less exclusive role than previously thought.
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