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When measured in non-pregnant subjects or in perfused hysterectomy, the ratio of drug concentration in endometrium or uterine artery versus systemic vein concentration is about two to sevenfold higher after vaginal than after systemic drug administration based on reports for progesterone [24], danazol [25], thalidomide [26].
The ATP costs in the polymerization of amino acids and nucleotides were predicted based on reports for P. chrysogenum [ 32].
These doses of ATR were chosen based on reports for the rat of an oral median lethal dose (LD50) of 1,869 mg/kg (U.S. EPA 2001), a no observed adverse effect level (NOAEL) of 3.3 mg/kg/day, and a lowest observed adverse effect level (LOAEL) of 34.5 mg/kg/day for this route of administration measured as body weight loss.
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Assuming regulatory approval and based on reporting for the last nine months, HP/Compaq will have $11.35 billion in services revenue and $1 billion in earnings, compared with $26.38 billion in revenue and earnings of $3.67 billion for IBM Global Services.
The choice of the above variables was made based on reports available for enhanced PYT production by solid state fermentation (Bhavsar et al. 2013).
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