Exact(1)
Therefore, predicting whether the paracetamol concentration will be above the nomogram line based on reported dose is of significance.
Similar(59)
The dose, route and timing of these treatments were based on reported half-life for these agents, prior publications and preliminary experiments demonstrating efficacy [6], [21].
In our patient the 6 month duration was chosen based on typically reported dosing periods.
Mice were randomized into 3 groups (n = 8 12/group) receiving either vehicle (controls) or INC280 (10 mg/kg/d or 20 mg/kg/d) by oral gavage based on previously reported dosing schedules [ 15]; treatment started 7 days after tumour cell inoculation.
This dose was chosen based on reports in the literature demonstrating effective dose ranges for behavioral studies in mice without adverse effects [51], [52].
The 0.5 mg/kg LPS dose was preferred to higher doses based on reports that below 3 mg/kg, the endotoxin does not cause BBB disruption [45].
The intraperitonial route for administration of the CCE in this dose was chosen based on reports in our studies which have shown that after testing several doses of cactus this dose is appropriate to induce a good prevention against oxidative stress induced by mycotoxine zearalenone in balb/c mice [ 39, 40].
This cutoff is based on reports that supplementation with increasing doses of selenomethionine leads to increases in the concentration and activity of glutathione peroxidases until the dose response relationship reaches a plateau at plasma Se levels between 70 and 90μg/LL (Food and Nutrition Board 2000; Xia et al. 2005).
The dose was chosen as the highest tolerated dose (because of blood pressure reduction) based on reports in the literature [14, 15].
The doses of radioactive tracers were determined based on reports about biodistribution of MIBI and BMIPP (Kubo et al. 1992; Torizuka et al. 1991).
The reported dose was based on the patient history which was confirmed on multiple occasions and cross checked with any collateral history from the family, friends or pre-hospital services (e.g. ambulance).
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