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To document the longitudinal reproducibility of the DLW method, 2 protocols, 1 based on repeated analysis of dose dilutions over the course of the clinical trial (dose-dilution protocol) and 1 based on repeated but blinded analysis of randomly selected DLW studies (test-retest protocol), were carried out.
The European Commission [ 136] has defined the acceptability of an analytical method based on repeated analysis of PCB/OCPs in a CRM as follows: −50% to +20% for analytes in the range of <1 μg/kg −30% to +10% for analytes >1 μg/kg to 10 μg/kg −20% to +10% for analytes >10 μg/kg.
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For PolyWare, the precision has been described in the range of 0.02 mm (max 0.28 mm) for 2D wear measures and 0.07 mm (max 0.41 mm) for 3D wear measures based on repeat analysis of the same zero wear laboratory radiographs.
Further statistical analysis will be based on repeated measures analysis of variance.
For this automated annotation step we carefully designed regular expressions based on repeated manual analysis of the annotation results.
Pain scores are presented as model-based mean values for change from baseline, 95 % CIs, and corresponding P values, based on repeated measures analysis of variance (ANOVA).
Given that there are no acceptable methods for calculating sample size for this design, sample size estimates are based on Repeated Measures Analysis of Variance (RM-ANOVA).
The annual loss based on repeated measures regression analysis of a subset of reefs that were monitored for multiple years from 1997 to 2004 was 0.72 % (n = 476 reefs, 95% CI: 0.36, 1.08).
The power calculation is based on repeated three-group analysis.
Continuous variables were analyzed using a restricted maximum likelihood analysis, based on repeated measures approach, including the independent 'treatment' variable, the repeated 'time of assessment' variable and their interaction as factors.
The statistical significance of these changes (except for CRP) could also be confirmed by the analysis based on repeated measurements.
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