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At the end of the study period, all subjects were divided into either the controlled or uncontrolled group based on remission criteria proposed previously, 2 and the linear mixed model was used to observe the changes in the AcroQoL scores of the two groups over the entire 24 weeks and whether these changes differed between the two groups.
Similar(59)
Remission was based on the Remission in Schizophrenia Working Group definition [ 7].
The primary endpoint in CHARM was clinical remission and the study was statistically powered based on predicted remission rates.
One of the most important aspects of our study is to evaluate the effectiveness of the intervention based on the remission of symptoms.
The sample size of the MOBIL study was calculated (80% statistical power, α-level of 0.05 and equal distribution to the treatment groups) based on anticipated remission rates of type 2 diabetes and obstructive sleep apnoea.
As an alternative approach to the cluster analysis approach, a remission analysis based on the Andreasen remission criteria was performed [ 5].
Post hoc analyses assessed the proportion of patients who achieved ACR/European League Against Rheumatism EULARR) Boolean-based remission (based on 66 swollen/68 tender joint count).
The Kaplan-Meier curves and log-rank test were used to assess the difference of survival functions based on the five remission definitions.
A decision to continue with escalation of MTX was made based on disease activity (remission - yes or no) and laboratory abnormalities (none or mild, moderate or severe).
Based on their clinical remission response, the subjects were divided into two groups: selective serotonin reuptake inhibitors (SSRIs) and SSRIs plus quetiapine.
Primary efficacy was evaluated based on the clinical remission rate at 2, 4, and 6weeks during intensive GMAA, and 13, 26, and 52weeks after starting treatment.
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