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The ability, using MG-MRD, to identify a group with exceptionally high post-transplant mortality primarily from disease relapse sets the stage for MRD-based clinical interventions based on relapse risk.
Based on relapse rates, studies indicate that allogeneic and autologous transplants provide better antileukemic activity than intensive chemotherapy schedules.
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Our primary objective was to determine the prognostic performance of BCI based on relapse-free survival (RFS).
The Kaplan Meier survival curves were drawn based on relapse-free rates; log-rank tests were used to compare these rates differentiated by p16, UGT2B17-deletion and disruptive TP53-mutations.
Based on relapse-free survival analyses of the 54 cases with known clinical outcome (30 younger women, 24 older women), there was a trend supporting a less favorable prognosis for the younger age cases (P = 0.09) and PR-negative cases (P = 0.08).
We present the results of the external validation of the previously developed prediction based on relapses in addition to well-known prognostic factors [ 6].
A pleurectomy was considered but was refused by the patient, considering his poor overall prognosis based on the relapse of T-PLL.
The year prior to HSCT was chosen to characterize current use based on high relapse rates within 1 year following a reported cessation attempt in both the general population and following cancer treatment 33-900%).
In order to further investigate whether the observed changes in TCR repertoire and diversity were GVHD-related and GVL-independent, we further compared the TCR repertoire between GVHD and non-GVHD patients based on their relapse status.
A recent study from Edinburgh, based on 108 relapses (including 35 cases of CBC) makes a similar point, and reports that treatable breast relapse occurred at a constant rate for at least 10 years (Montgomery et al, 2007).
The first prediction of the risk of death P R e c is calculated based on all relapses information.
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