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In the UK, asthma in adults has been studied more thoroughly.[22], [23] A review concluded that the prevalence plateaued during the 1990s after increasing since the 1970s ,[12] aconclusion, however, in part based on registry studies and studies of selected populations.[22] The present study corroborates these findings despite the higher asthma prevalence in the UK.
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Because the study was based on registry and survey data, no ethical approval was required.
No ethical approval was required according to Danish legislation and the National Committee on Health Research Ethics in the Central Denmark Region as the study was based on registry and survey data (j. no. 181/2011).
The study was based on registry data only, and study persons were not contacted by the researchers.
Misclassification of drug exposure based on registry data will impede studies.
Recent studies based on registry data and direct clinical observations have resolved the issue of dose response to Imig by showing incremental improvements in clinical parameters based on increasing doses of Imig [18], [46].
Limitations concerning completeness and coverage are inherent in observational studies based on registry materials.
Further, the steering committee suggests and executes research studies based on registry data.
Although it is very important that data are gathered on patients who might usually be excluded from clinical trials, there are several limitations to studies based on registry data.
Although studies based on registry data provide valuable insights into major differences in implant rates across countries, they are rarely used to evaluate the impact of ICDs [ 10, 12- 14].
Two large studies based on registry cohorts [ 16, 45] reported that the reason for discontinuation of a first TNF-α inhibitor was likely to explain the reason for discontinuation of a second TNF-α inhibitor, while the findings from another large registry cohort could not confirm this relationship [ 50].
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