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The new algorithm C++ code was written based on reference from Andreas Geiger's LIBICP code [28].
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Additional papers were included based on references from the original 44 publications.
CRC patients' quality of life were measured using EORTC QLQ-C30 questionnaire and effectiveness estimates for monoclonal antibody (Cetuximab and Bevacizumab) treatment were modeled from study respondents based on references from other studies.
The new model includes the following new features: (1) A fitting model based on reference values from pseudoinvariant areas that have been automatically extracted from existing reflectance products (Terra MODIS MOD09GA) that were selected also automatically by applying quality criteria that include a geostatistical pattern model.
GenADA genotype data (after QC) were imputed using Mach (http://www.sph.umich.edu/csg/abecasis/mach/, [42] [43]) based on reference haplotypes from HapMap III phased data (release 2).
FEV1 and FVC as percentage of predicted were calculated based on reference values from a healthy non-smoking Thai population [ 22].
Probe design was based on reference sequences from the UCSC genome browser (http://genome.ucsc.edu) human build hg19 (chr.7: 145713453–148218086 bp) and chimpanzee build panTro2 (chr.7: 146592820–149139309 bp).
Shift tables showing laboratory test values classified as below normal, normal, and above normal, based on reference ranges, from baseline to each visit, were also produced.
It presents longitudinal and cross-sectional PRO charts, in which the PRO scores are automatically color-coded based on reference scores from specific patient groups (patients with e.g., same age, sex, diagnosis, and treatment phase).
Flag System: Based on reference values from literature or previously collected data, the Flag System allows for the quick identification of patients with clinically relevant problems, using cut-off scores or score distributions.
Standard deviation scores (SDSs) of height, weight, body mass index (BMI), and BSA were calculated based on reference material from Danish children (Andersen et al. 1982; Nysom et al. 2001).
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