Sentence examples for based on receptor binding from inspiring English sources
The focus was on tests based on receptor binding and receptor activation in cell cultures measured via reporter gene activation or cell proliferation: Competitive ligand-binding assays measure the binding affinity of a substance to an (isolated) receptor.
Further, peptides isolated by phage display screenings are commonly selected based on receptor binding but not on subsequent internalization, nuclear transfer, and transgene expression.
The dose of OH-PCB-61 was twice that of OH-PCB-30; therefore, a similar incidence of CV tract tumors was expected based on receptor binding affinities.
Simplistic models based on receptor-ligand binding have been previously developed for cell orientation and migration [22].
Specific adhesion is mediated by certain adhesins which can be differentiated based on their receptor binding specificity.
The expected HGB responses of these ESA molecules on the surface were located based on their receptor binding affinity and linear clearance.
For dietary and ADI comparisons that required combining exposure to individual estrogens, total estrogen exposure was expressed as estradiol equivalents (E2-eq), which were estimated based on alpha receptor binding for E1, E2, and E3 (assumed to have relative biological activity of 0.1, 1.0, and 0.038, respectively).
The function-first approach is based on bioassays, receptor-binding assays and genetic analysis, while the peptide-first approach is based on cDNA cloning of precursor, using neuropeptide precursor processing enzymes, peptidomics, etc. (7).
Based on sigma receptor (SR) binding studies, two subtypes have been characterized: sigma-1 receptors (S1Rs) and sigma-2 receptors (S2Rs) [1].
Next, we determined whether the computational method was able to discriminate between avian viruses and human viruses based on the predicted receptor binding preferences.
