The numbers affected will continue to climb as the population ages, prompting an escalating race to develop more effective treatments and, perhaps, even preventives, including measures based on recently identified genetic factors that raise the risk of developing the disease.
Based on recently identified synthetic TLR2 agonists [3] and antagonists [4], a shape and chemical-feature based similarity search was performed against a library of 260.071 compounds provided by the National Cancer Institute (NCI) [5].
The design of these compounds is based on a recently identified lead compound from a high throughput screen.
The Varelisa® Sm assay (reference 18296; Phadia GmbH, Freiburg, Germany) is based on a recently identified peptide derived from the SmD3 sequence [ 14].
Based on recently published genome-wide scans that identified loci associated with age of menopause, we also sought to test our hypothesis that follicle number and menopausal age share underlying genetic associations.
Based on recently released tomato whole-genome sequences, we identified in silico 32 histone acetyltransferases (HATs), 15 histone deacetylases (HDACs), 52 histone methytransferases (HMTs) and 26 histone demethylases (HDMs), and compared them with those detected in Arabidopsis (Arabidopsis thaliana), maize (Zea mays) and rice (Oryza sativa) orthologs.
Statistical assumption is based on recently published trials [ 14].
Based on this approach, we recently identified CO3-610, a specific peptide fragment of type III collagen generated by MMP-9, as a potential liver fibrosis biomarker, and developed an ELISA assay to quantify it in serum [ 13].
Importantly, the observed potentiation of migration supports the conclusion, based on experiments with a recently identified inhibitor of EPAC [1], that EPAC (and specifically EPAC1) is important for migration of PDAC cells and that EPAC inhibition suppresses migration.
Possible therapies for AD include peptides based on the Aβ sequence, and recently identified small molecular weight compounds designed to mimic these, that interfere with the aggregation of Aβ and prevent its toxic effects on neuronal cells in culture.
These included three ITS sequences of R. griseocarnosa recently identified based on three specimens of Dahongjun in southern Yunnan [20] and 12 ITS sequences from GenBank representing 5 closely related species in Russula (R. vinosa, R. claroflava, R. occidentalis, R. decolorans, R. xerampelina; Supplemental Figure S1).
