In this review, we critically evaluate previous attempts to use non-specific antioxidants as neuroprotectors and emphasize new approaches based on recent breakthroughs in understanding of enzymatic mechanisms of lipid peroxidation associated with specific death pathways, particularly apoptosis.
The correlation is essentially upgraded based on recent advancements in understanding and modelling of combustion phenomena relevant to hydrogen air vented deflagrations and unique large-scale tests carried out by different research groups.
Here, we developed a quantitative model of fitness dynamics on genealogical trees, which is based on recent progress in understanding the statistical structure of genealogies in adapting populations (Neher and Hallatschek, 2013).
Based on recent developments in understanding miRNA biology and mechanisms, at least three main models can be proposed by which miRNAs could modulate gene expression post-transcriptionally: (1) inhibition of translation initiation, (2) postinitiation inhibition of translation, and (3) mRNA destabilization.
Based on recent advances in our understanding of these contrasting strategies of nutrient acquisition, we provide an explanation for the distribution of mycorrhizal species on less P-impoverished soils, and for why, globally, cluster-bearing species dominate on severely P-impoverished, ancient soils, where P sensitivity is relatively common.
The hypothesis is based on recent improvements in the understanding of pain processing pathways in the central nervous system, and in particular the role of limbic structures, especially the anterior cingulate cortex, hippocampus and amygdala, in chronic and affective pain perception.
Based on recent advances in the understanding of the pathophysiology of tinnitus and based on an increasing amount of promising pilot data, rTMS seems to hold high potential as a new treatment tool.
Based on recent advances in our understanding of Crx in the rodent pineal gland, we here suggest that homeobox genes play a role in adult pineal physiology both by ensuring pineal-specific Aanat expression and by facilitating cAMP response element-based circadian melatonin production.
Even instructional innovations based on recent learning science research have limitedly improved students' understanding (Bransford et al. 2000).
Reconstruction of protein-protein interactions are important for understanding cellular networks [ 17], and based on recent development of new high throughput technologies PPIs have accumulated rapidly [ 18].
