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Indeed, a true biological interaction between CFH and LOC387715 would be plausible based on recent cell biological data by Kanda et al. (2007) and Fritsche et al. (2008) showing that LOC387715 is localized to mitochondria [32], [33] and on the earlier evidence that mitochondria activate complement [52].
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Based on recent evidence that dendritic cells (DC) are important for activation of memory CD8+ T cell reactivity to influenza A virus, herpes simplex virus type 1 and human cytomegalovirus [14], [15], [16], [17], [18], we hypothesized that DC could enhance the breadth of T cell responses to HIV-1, particularly in persons on ART.
Based on recent evidence that NKT cells reside in liver vascular compartment, we developed a simple method to isolate NKT cells by perfusion with PBS-containing 10 mM of EDTA.
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Based on recent work in gut cells by other researchers, Rosenblatt also suspects this mechanism will be found in many simple epithelial systems.
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However, based on recent promising reports from the clinic, autologous cell-based therapy could soon become a standard procedure in the treatment of urological diseases.
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