Sentence examples for based on reactivating from inspiring English sources

Preliminary therapies were based on reactivating p53 directly, but more recently the focus has been on the isolation of small molecules which mimic the function of proteins that stabilise p53.

Based on their ability to reactivate tumor suppressor genes silenced by DNA methylation and chromatin modification, DNA methylation inhibitors and HDACis are emerging as a new class of anticancer agents and are in many ongoing patient treatment regimens [30] [32], [44] [46].

One project was reopened in December 2009 when the security situation improved, and another in late 2010 based on concerns that population displacement might reactivate historic foci.

Based on our investigations we generally recommend using reactivated GAC to reduce the environmental impact and to carry out tests on pilot scale to collect reliable data for process design.

Lastly, the scalability of the concept is demonstrated by reactivating an 8-cell stack based on a commercial design.

Lastly, it is also important to note that certain parts of the terraces can become dry and others can be reactivated after prolonged dry periods (based on consecutive visits to the springs during 2003 to 2006 and historical records).

Our results roughly based on the same approach indicate that HCMV can be reactivated in scattered cells and in only a few cases of human gliomas.

Based on these data, we compared HBcAb positive patients who reactivated infection with those who did not, to search for any event predictors, so to obtain a staging of the risk of reactivation.

The selective activation of telomerase and inactivation of p53 in the majority of cancers has lead to therapeutic strategies based on inhibition of telomerase (as discussed above) in addition to reactivating p53.

The Hines Creek landslide occurred between June 9th and June 25th , 1990(based on Landsat 5 Thematic Mapper bracketing dates) and was a reactivated, retrogressive earth slide, with a rupture surface in glacial sediment (LTA4).

SRR thus appears to be based on positive feedback in which stronger synapses are more frequently reactivated, resulting in repeated occurrences of L-LTP.