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However, persistence, changing approaches and making modifications based on rationale and evidence, resulted in sufficient data saturation for our study.
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Based on rationale provided by the Starling curves and Guyton model on cardiac function, CVP is determined by the interaction of cardiac function and the return of blood to the heart.
Mean greenness and variation in greenness were then classified into tertile groups for analysis based on rationale previously published elsewhere [ 35].
Based on this rationale, and in order to develop a more profound understanding of these processes and their possible influence on developing bone microarchitecture, we should carry on measuring bone mineral and body composition parameters parallel to (nutritionally dependent) hormones.
Not feminist - based on robust rationale and action - but female in the traditional sense which the feminists set out to change: compliant, irrational, emotionally simplistic.
The juvenile toxicity study design is approached case-by-case based on scientific rationale and should mimic the pediatric clinical trial.
Finally, guidelines, treatment protocols, and consensus-based recommendations for several major diagnoses relevant for intensive care treatment have been developed in order to secure the transfer of best practice of hemodynamic management based on pathophysiological rationale and scientific evidence.
Based on the rationale and evidence of safety, this approach appears to be a reasonable option as more information is acquired.
Based on this rationale and the paucity of studies investigating the predictive value of AMPK activation in patients treated with anti-angiogenic drugs, we designed a pilot retrospective study to analyse activation of the AMPK pathway in CRC patients treated with bevacizumab plus chemotherapy and to correlate it with patient clinical data and survival.
The Centers for Disease Control report comprises three classes of evidence: recommended strategies are based on strong rationale and suggestive evidence, suggested strategies may be supported by suggestive clinical or epidemiologic studies, and no recommendations are given for practices for which insufficient evidence or consensus regarding efficacy exists.
Of these, some are based on pathophysiologic rationales and some have been adopted from other fields of medicine.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com