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This work not only offers a new and easy strategy for synthesizing viologen-bridged PANI materials through covalent bonding, but also paves the way for the development of high-efficient sandwich-type resistive random access memory (RRAM) devices and the all-solid-state supercapacitors based on rational designed heterofilms.
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Here, we report the humanization of mouse 38C2 based on rational design guided by molecular modeling.
A library of pentapeptides containing the sequence –Y X Y– based on rational design was screened with six different lectins.
Up to now, we have resolved the crystal structure of PI4KIIα (Zhou et al., 2014) and subtype-specific PI4KIIα inhibitor candidates based on rational design are currently screened for mimicking the effects observed here for PI4KIIα siRNA knockdown.
The effect of Ce substitution on the crystal structure, morphology, electrochemical performance and kinetic property of NVP is investigated based on rational design and synthesis optimization.
Based on rational design, three further mutations of the mutant H43T (denoted H43T/Δ(139–144)/S134T/A137V/L138D/V139I, H43T/S85G and H43T/Y87F) were constructed and produced γ-CD with yields of 20%, 20%and39%9%, respectively.
Strategies based on rational design require significant a priori knowledge and often fail to take a holistic view of cellular metabolism.
Using R-3-chloromandelic acid as a model substrate, a total of 53 mutants were constructed based on rational design in the two rounds of screening.
Improvements in specific cellulase activities for noncomplexed cellulase mixtures can be implemented through cellulase engineering based on rational design or directed evolution for each cellulase component enzyme, as well as on the reconstitution of cellulase components.
Improvements in specific cellulase activities for non-complexed cellulase mixtures can be implemented through cellulase engineering based on rational design or directed evolution for each cellulase component enzyme, as well as on the reconstitution of cellulase components.
A new concept of forming polymeric artificial SEIs (A-SEIs) based on rational design of multifunctional polymer-blend coating to achieve favorable electrode/A-SEI/electrolyte interfacial properties is described.
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