Sentence examples for based on rational design from inspiring English sources
Here, we report the humanization of mouse 38C2 based on rational design guided by molecular modeling.
A library of pentapeptides containing the sequence –Y X Y– based on rational design was screened with six different lectins.
Up to now, we have resolved the crystal structure of PI4KIIα (Zhou et al., 2014) and subtype-specific PI4KIIα inhibitor candidates based on rational design are currently screened for mimicking the effects observed here for PI4KIIα siRNA knockdown.
The effect of Ce substitution on the crystal structure, morphology, electrochemical performance and kinetic property of NVP is investigated based on rational design and synthesis optimization.
Strategies based on rational design require significant a priori knowledge and often fail to take a holistic view of cellular metabolism.
Using R-3-chloromandelic acid as a model substrate, a total of 53 mutants were constructed based on rational design in the two rounds of screening.
This work not only offers a new and easy strategy for synthesizing viologen-bridged PANI materials through covalent bonding, but also paves the way for the development of high-efficient sandwich-type resistive random access memory (RRAM) devices and the all-solid-state supercapacitors based on rational designed heterofilms.
We analyze the current status of the discrete and high-throughput component-based approaches; and propose new process-centered approaches that would integrate components with the help of computational modeling such that future biomaterials and tissue engineering research will be less trial and error but more based on rational-design.
Based on rational drug design approach, a series of novel thiazolidin-4-ones bearing different aryl/heteroaryl moieties at position C-2 and N-3 are synthesized and evaluated as potent inhibitors for human immunodeficiency virus type-1 reverse transcriptase enzyme (HIV-1 RT).
Iclaprim, a new selective dihydrofolate inhibitor was synthesized based on rational drug design.
Herein, based on rational drug design strategy, hydroxamic acid derivatives of olaparib were constructed as dual PARP and HDAC inhibitors.
