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In this approach the experimental dataset was divided into training (83%) and test (17%) sets and the best model was chosen based on randomized trial distributions consisting of five compounds in a test set with a wide range of activity profile and superior values of statistical parameters such as Q2 and R2 values.
Our simulations were based on randomized trial results, and it may be difficult to replicate these findings in daily practice.
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The Swedish data was not based on randomized trials but suggested that bigger clinical trials comparing the two types of stents were needed, he said.
"There's clear data based on randomized trials, primarily from Europe, that shows P.S.A. testing reduced mortality," he said.
In medical oncology, changes in practices are almost always based on randomized trials but medical history shows that it is different in surgical oncology.
Guidelines are typically based on randomized trials that recruit the most straightforward patients.
High quality evidence was considered to be based on randomized trials (RCT) or systematic reviews (SR /meta-analysis (MA).
Nevertheless there is only limited evidence to support the superiority of extra-articular glucocorticoid injections based on randomized trials [ 9].
Although this is based on randomized trials, the quality of the evidence is moderate, because the confidence intervals are very wide.
This recommendation is based on randomized trials that have demonstrated that treatment of asymptomatic bacteriuria is not beneficial in other patient populations [ 18- 22].
Drug-eluting stents were accepted for extensive clinical use based on randomized trials involving relatively few and selected patients, with angiographic follow-up data serving as the primary end point.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com