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Ten studies (67%) were based on randomised clinical trials (RCTs) with time horizons ranging from 6 to 24 months.
In our study, using local epidemiological estimates and based on randomised clinical trials data, apixaban resulted a cost-effectiveness alternative to warfarin according to local willingness to pay thresholds.
Clear indications for different modes of treatment based on randomised clinical trials have not yet been defined.
Current guidelines on breast cancer screening are mostly based on randomised clinical trials that were performed in the 1970s and 80s.
Although papers on physical treatment for TMD have been published since 1952 [ 2], the first evidence for its effectiveness based on randomised clinical trials (RCTs) was described in the studies of Kopp and Stenn et al. [ 3, 4].
Therefore, current decision making is based on randomised clinical trials which – by their nature – are designed to statistically evaluate the response within a total cohort rather than the response of individual patients.
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Many studies were based on randomised controlled clinical trials.
Most obviously this is a hypothetical modelling study and the outcomes are not based on randomised controlled clinical trial data (which would be ethically impossible to acquire).
In 2012, WHO and ERS launched the ERS/WHO electronic consilium [ 160]. 1) At present, there are no clear guidelines based on randomised controlled clinical trials to guide clinicians in the management of patients with MDR/XDR-TB.
Current scientific knowledge for clinical research is based on randomised control trials (RCTs) that have been synthesised in systematic reviews (SRs) and meta-analyses (MAs), which together comprise the 'gold standard' of scientific evidence.
These results may be more generalisable to routine clinical practice than models based on randomised controlled trial (RCT) data, and therefore more appropriate to assess the cost-effectiveness of routine use treatment protocol in the NHS.
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