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We assessed the significance of PLV with 2 different surrogate methods: one is based on random shuffling of data and the other on random resampling of data.
The statistical significance of NES score is estimated by a permutation test based on random shuffling of the phenotype or tag (gene) labels.
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Here, we not only examine the thermodynamic stability of miRNAs in an analogous manner to that done by Bonnet et al. [ 21] but also using a background model, based on random and shuffled pseudo pre-miRNAs, that maintain the stem-loop structure as in the real pre-miRNA (see Methods).
We tested two different genome shuffling strategies, one based on random mating and one based on targeted mating.
For both genome shuffling based on random mating and on targeted mating, we also investigated the dynamics of not applying any selection in between the different rounds of genome shuffling.
A novel random shuffling approach was applied for EA and EB to compare the correlation coefficients obtained from real data sets to those estimated based on random chance.
Generalities based on random observation will get you into trouble.
The new survey was based on random telephone interviews from March 1 to Aug. 20.
Based on random sampling.
Significance assessment is based on random permutations.
All based on random effects meta-analysis.
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