The effective doses were well within what would be predicted safe in humans based on published trials [6], [7], [50], [51].
Studies based on published trials have indicated that methodological quality is comparable for industry-sponsored and non-industry trials [ 12– 12].
Strengths of the study included a large practice and patient sample size and an intervention based on published trials and delivered at an intensity feasible in primary care.
In conclusion, our meta-analysis based on published trials in endemic areas showed that the CCRT was the most effective treatment modality for the improvement of overall survival in locally advanced NPC.
Non-industry protocols more often received comments related to methodology and statistical analyses and the selection of participants than industry-sponsored protocols, while research based on published trials indicated that methodological quality was comparable for industry-sponsored and non-industry trials [ 12– 12].
Treatment regimens were based on published clinical trial protocols.
Yet, until "hard" major vascular event data are published, we feel that the initial statin dose should be fixed and based on published clinical trial data (i.e., 10 mg atorvastatin or 40 mg simvastatin), thus changing the current concept of treat-to-target LDL with statins in this subset of patients.
27, 29 The results of VECTIS show that the use of panitumumab monotherapy in heavily pretreated mCRC patients was associated with a similar effectiveness and safety profile to that which would be expected, based on published clinical trial data in this setting.
Based on published hybrid performance trials in eight Texas counties, we developed standard data sets of 10-year simulations of maize and sorghum for these eight counties with the Agricultural Land Management Alternatives with Numerical Assessment Criteria (ALMANAC) model.
Therefore, conservative estimates of efficacy over 12 months were based on published reports from trials among high-risk methamphetamine users in the U.S. using a similar brief behavioral intervention [11].
