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These Affymetrix-based arrays encompass a total of 13 genes that were selected based on published mutation frequencies, recessive inheritance patterns and severity of genetic impact on patient outcome.
Estimates were based on published mutation rates for land snails.
Based on published mutation rates (Lang and Murray 2008; Lynch et al. 2008), we predicted zero to two mutations per WT genome and observed a slightly higher but comparable rate (median = 2.5 mutations/genome; range, two to four mutations).
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This estimate was based on published measurements of the frame-shift mutation rate in mononucleotide repeats in Mycobacteria and other bacteria (see Methods).
With an empirical estimate, based on published generation times [37], [38] and genomic mutation rates [39] for C. jejuni, the scale bar would represent a period of 42,200 years (95% CI 2,690 661,000) and with the Ochman and Wilson method [35] the scale bar would represent 7.6 My [32].
Based on published reports, the overall frequency of ER mutations in metastatic, ER-positive breast cancers ranged from 11 to 54.5%, depending on the clinical characteristics of the cohort and the method of identification [ 22, 28, 30, 31].
Mutation classification was made based on published studies and analysis using PolyPhen.
Healthcare costs based on published hospital costs.
Based on published reports, Woods found married life unfulfilling.
The loperamide dose was selected based on published data.
This classification was based on published studies [11], [28], [29].
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