The PK models and prior distributions for fixed and random effects for ketoconazole and MDZ are based on previously published meta-analyses.
In February 2014, the FDA convened another advisory committee meeting based on recently published meta-analyses and observational studies calling into question some of the previous assumptions guiding the US NSAID class labeling.
Table 4 summarizes DTI findings in AD and MCI based on the two recently published meta-analyses [ 78, 79].
By comparing our findings on recently published meta-analyses with those of Attia et al. (4) on 37 meta-analyses published before 2000, we can see improvement over time in both reporting and conduct.
We implemented these in the model using risk equations that were developed by the Canadian Centre for Addiction and Mental Health (CAMH) using published meta-analyses based on systematic literature reviews and were previously used for a population-based analysis.
The majority of published meta-analyses are based on summary or aggregate patient data (APD).
While the relative advantages and disadvantages of meta-analyses based on either APD or IPD have been debated in the medical literature, the majority of published meta-analyses continue to be based on APD.
We appraised the methodology, execution and quality of the five published meta-analyses that are based on the five randomized controlled trials which compared cardiotocography (CTG +ST analysis to cardiotocography.
33 This method, used in previously published meta-analyses, 4 34 is based on the fact that with logistic distributions and equal variances in the two treatment groups the log odds ratio corresponds to a constant multiplied by the standardised difference between means.
