Importantly, six lncRNA partners of WDR5 are known to be important for ESC pluripotency or differentiation based on published knockdown experiments (revised Figure 4B).
As indicated in response to point 1 above, WDR5 RIPiT-seq revealed six lncRNA partners of WDR5 are known to be important for ESC pluripotency or differentiation based on published knockdown experiments (revised Figure 4B).
The dose/stimulation time of stearate used for all experiments was based on published data [ 1, 4] and our previous observations that insulin resistance is present after 6 h stearate stimulation.
The supposition of a potential biological model will require further experiments but, based on published studies, we suppose that the correlation that we observed between rs4430796 GG genotype and reduced OS in patients treated with chemotherapy could support the hypothesis that G allele reduces chemosensitivity through HNF1B overexpression.
The nucleotide targets of the FAS coding sequence were selected based on previously published experiments (De Schrijver et al, 2003) and computer-based target analysis using siRNA Target Finder (Ambion Inc., Austin, TX, USA).
The concentration of AGuIX particles used for the experiment is given in gadolinium equivalent species and chosen based on published literature (Rima et al. 2013).
Time of exposure was based on published studies, or in cases where no comparable studies were available, on small scale pilot experiments.
One is a zero-pressure gradient model, and the second is based on published experimental data of the skin friction on a rough circular cylinder, but with smaller roughness than was used in the experiments.
The Compound 1 gene set is based on previously published experiments examining differentiation in three different strains.
Healthcare costs based on published hospital costs.
