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Subgroup analyses were defined, a priori, based on PROWESS subgroups [ 15, 16].
The somewhat smaller effect of DrotAA on mortality leads to lower lifetime QALY gains compared with those of previous studies based on PROWESS [ 18, 19, 21, 22, 62].
Instead, based on PROWESS data, d-dimer appears to be a marker that the patient received DrotAA, not how well the patient responded to DrotAA.
In brief, the previous study used audit data from routine clinical practice and applied inclusion and exclusion criteria based on PROWESS [ 13].
Previous studies reported that DrotAA was cost-effective for adults with severe sepsis [ 18- 23], but because the studies were based on PROWESS, these findings may not apply to routine clinical practice.
Based on PROWESS (Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis) [ 4, 22], CEC CAP patients were segregated into quartiles of APACHE II scores of less than 20 (n = 91), 20 to 24 (n = 149), 25 to 29 (n = 127), and greater than 29 (n = 128).
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Writing on the popular site LifeNews, one of the best-known Russian Orthodox Church priests, Vsevolod Chaplin, even called on Russia to create its own Olympics based on "martial prowess" rather than the "quasi-pacifism" of Olympic founder Pierre de Coubertin, who he complained was a Freemason.
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