Sentence examples for based on protein structure from inspiring English sources
(A) All protein-based pharmacophores identified based on protein structure of factor Xa (PDB: 1MQ6) without inclusion of information about known active ligands.
Traditionally, biochemical studies have been based on protein structure and function with emphasis on metabolism and bioenergetics.
Kennewell et al. [10] developed a method for comparison and superimposition of all holo proteins in the PDB based on protein backbone atoms, which allows ligands to be transposed between protein binding sites based on protein structure superimpositions.
As a new approach to address this complex problem, a synergistic strategy is presented, which is based on protein structure similarity clustering and natural product structure as guiding rationales.
The two fragment-based sequences perform better than the secondary-structure sequence but not well enough at this stage to be a viable alternative to more computationally intensive methods based on protein structure alignment.
The PI3K family is divided into several classes based on protein structure and substrate targets.
Nevertheless, a recent in silico analysis based on protein structures available in the protein structure database has pointed out the correlation between the presence of large numbers of aromatic clusters and the thermal stability of proteins [5].
Because no structural data of neither Mal d 1 nor Cor a 1 were available, models were calculated based on protein structures of highly homologous allergens.
As a well studied topic, those computational approaches that have been developed to predict drug targets based on protein structures are referred to in a recent review paper by Tan et al. [ 8].
Previous studies showed that the unique design of the peptide polymer conjugate based on protein tertiary structure as the headgroup is the main design factor to achieve high kinetic stability.
The proteins analyzed here all have many homologue sequences, but these serve to exemplify the usefulness of our approach in the identification of binding sites based only on protein structure.
