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This paper introduces an integrative approach, IAMPC, to classify membrane proteins based on protein sequences and protein profiles.
For example, Swiss-Prot [21] is based on protein sequences, PDB [22] on protein structures and GenBank [23] on nucleic acid sequences.
The current version of PyBioMed could calculate 775 chemical descriptors and 19 kinds of chemical fingerprints, 9920 protein descriptors based on protein sequences, more than 6000 DNA descriptors from nucleotide sequences, and interaction descriptors from pairwise samples using three different combining strategies.
After the rise of molecular genetics in the 1950s, the field of molecular evolution developed, based on protein sequences and immunological tests, and later incorporating RNA and DNA studies.
Phylogenetic trees were also reconstructed based on protein sequences.
Until now, a number of feature extraction methods based on protein sequences have been proposed.
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To examine this possibility, we identified gene paralogs based on protein sequence homology (Table S3).
The entire interface between 14-3-3β 14-3-3β 14-3-3βand is similar in ExoS and ExotheSupplementART Fig. 5) andomained on proteis similare comparinon, appExoS to be well conserved in other 14-3-3-dependent toxins (Supplementand Fig. 6).
Functional description of protein domains was annotated by InterProScan based on protein sequence alignment method, and the InterPro domain database was used (Hunter et al. 2009).
As a result, developing a robust and effective computational approach based on protein sequence to detect SIPs has become more and more important.
In the work, we presented a novel computational approach named WELM LAG, which combined the Weighed-Extreme Learning MaclassifierM) classifier with Local Average Group LAGG) to predict SIPs based on protein sequence.
More suggestions(16)
based on enzyme sequences
based on seed sequences
based on protein identities
based on sediment sequences
based on training sequences
based on globin sequences
based on hemagglutinin sequences
based on reference sequences
based on protein motifs
based on protein diagnostics
based on cDNA sequences
based on promoter sequences
based on protein levels
based on protein similarities
based on intron sequences
based on video sequences
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