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MALDI-TOF mass spectrometry (MS) has been suggested as a fast and reliable method for bacterial identification [10], [11], based on protein profiles characteristic of each microorganism.
Levels of individual proteins were not extremely elevated in our study subjects, but based on protein profiles subjects may be differentially classified with lower or higher risk to develop a more pathological phenotype.
Alternatively, methods based on protein profiles account for the fact that sequence conservation might be very uneven across the length of two functionally related genes.
A long-term goal is to predict clinical outcome, based on protein profiles present in the serum early in the disease course.
Based on protein profiles we predicted that P. novae-zelandiae would accumulate more C4 glucosinolates than the other two species and would produce nitriles in hydrolysis instead of isothiocyanates.
It contains ∼97% of the strains included in the database and is more reliable than the 'MLST+AFLP+MLEE' supertree because MLEE, which is based on protein profiles, has a much lower resolution power than MLST and AFLP.
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But the first diagnostic test based on protein profiling will probably be an ovarian-cancer test from Ciphergen, the company whose machine started it all.
The same association was found in a more recent paper, based on protein profiling data [ 25].
Based on protein expression profiles of core regulatory proteins involved in the G1-S and G2-M phase transitions, we have identified three distinct cell cycle phenotypes in a series of 200 breast cancers: a G0 out-of-cycle state (18% of cases); a G1 arrested/delayed state (24% cases); and accelerated S-G2-M phase progression (58% of cases).
This property does not hold for scoring functions based on protein signature profiling, making this unattractive.
Aim of study was to develop a multidimensional model based exclusively on protein profiles labeled the protein profile prediction method (PPPM) to improve routine MC detection and typing.
More suggestions(16)
based on affinity profiles
based on expression profiles
based on protein identities
based on protein diagnostics
based on energy profiles
based on protein features
based on mission profiles
based on protein families
based on user profiles
based on protein levels
based on symptom profiles
based on risk profiles
based on attribute profiles
based on customer profiles
based on protein motifs
based on concept profiles
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