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We identified Cyclin A1 expression as a predictive marker for longer TTP after first-line cytostatic treatment in two independent data sets, one based on protein expression and one based on mRNA levels [ 22].
First, we tested our ability to distinguish the human and chimpanzee samples based on protein expression.
The development of new, innovative discovery approaches based on protein expression will greatly enhance the existing methodologies.
A proteomic approach that analyzes signatures based on protein expression would provide a robust method with power similar to that of the transcriptomic approach.
For the tree based on protein expression, we calculated the mean expression value for each gene based on expression levels in two experimental replicates (Table S2).
These statistics support the fact that the morbidity rate from CRC could be significantly reduced with new targeted methods of early cancer detection based on protein expression rather than on anatomical changes.
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No Notch pathway biomarker has been prospectively validated, but some recently published potential biomarkers based on protein and gene expression could be evaluated (Zhang et al, 2013).
Genes were classified into two groups based on protein and RNA expression correlation (Pearson's correlation coefficient greater than or equal to 0.5).
Based on protein structure and expression data, we also provide new insight into molecular functions of Nme proteins among vertebrates and raise intriguing questions on the roles of Nme proteins in gonads.
Besides the evidence, based on protein analysis, of increased expression of α-MyHC in our training groups, we decided to corroborate it using mRNA expression (Table 2).
Putative functions were assigned to the prioritized genes based on protein interaction networks and expression eQTL from our earlier study.
More suggestions(15)
based on protein interaction
based on protein testing
based on protein signature
based on protein structure
based on protein similarity
based on protein concentration
based on gender expression
based on protein probability
based on protein engineering
based on protein abundance
based on protein restriction
based on protein alignment
based on protein precipitation
based on protein level
based on protein motif
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