Sentence examples for based on prior observations from inspiring English sources
Inflammatory-related genes sit firmly in the candidate camp based on prior observations that the OA disease process can have an inflammatory component.
This is based on prior observations that homogeneous DNA duplexes melt over a fairly narrow temperature range, while more complex mixtures of DNA duplexes melt over a wider temperature range.
This notion is based on prior observations (unpublished) which have showed that maximal levels of hASM are detected within visceral tissue (e.g., liver, kidney, spleen and lung) almost immediately following systemic administration.
Based on prior observations, we anticipated that study of CD4 T-cell phenotypic markers (e.g., MHC Class II, CD25, etc). in 24 IPF subjects would provide very high power to detect intergroup differences, if their cellular characteristics resembled those of other patient populations [20].
We pre-determined three communities with good, modest, and poorly walkable environments based on prior observations.
One of the other safety concerns closely monitored on this trial was based on prior observations in the early phase I trials [ 19, 20] of significant peripheral neuropathy and neurologic AEs.
Two (CYP27B1 and HOXA10) were selected based on gene function potentially related to fertility, and one (a non-CpG island reaction for IFNG) based on prior observation of hypomethylation in tumor versus normal tissue (data not shown).
Our backpacks weighed 1 g, and based on prior observation (unpublished data), we chose a 1-week habituation period to ensure birds had fully recovered from any behavioural effects of the backpacks and any associated handling.
Briefly, the strength score for a mechanism is the weighted mean of the (log2) differential expression of genes, where the weighting factors are the direction of regulation of gene expressions in the mechanism based on prior observation (+1 for increase relationships, −1 for decrease relationships).
Re-sequence studies have investigated candidate genes based on prior genetic observations (changes in copy number or regions of genetic instability) or other laboratory observations and have defined critical somatic mutations in genes such as TP53 and PIK3CA.
Initial re-sequence studies examined individual candidate genes based on prior genetic observations (changes in copy number or regions of genetic instability) or those identified in animal or in vitro laboratory studies and have defined critical somatic mutations in genes such as TP53 and PIK3CA [ 4- 11].
