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As continuation of our research work on the development of new PPO inhibitors, a series of mono-carbonyl analogues of cyclic imides, N-phenyl pyrrolidin-2-ones and N-phenyl-1H-pyrrol-2-ones, were designed and synthesized based on previously established DFT-QSAR results.
Toxicity assessment was based on previously established methods [7, 28].
Strain construction was based on previously established engineering strategies (Seibold et al. [2006]; Uhde et al. [2013]; Meiswinkel et al. [2013a]; Gopinath et al. [2011]).
The design was based on previously established potent inhibition of the enzyme by oxa analogues (esters), which also act as substrates.
Sensitivity (SN) and specificity (SP) were calculated based on previously established cutoff points of the IVC/Ao ratio (0.8), the IVC collapsibility index of 50%, and a new cut off point of IVC collapsibility index of 80% or greater.
Some of the work features developing novel functions based on previously established arylene ethynylene folding systems, and others have designed and synthesized new arylene ethynylene foldable structures that aim to realize previously uncharted properties.
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In 57.4% of the flocks the timing and frequency of the anthelmintic treatments against gastro-intestinal parasites were based only on previously established routines and experience, together with regularity and when housing the animals (Table 2).
We based our analysis on previously established criteria for microcirculatory perfusion [ 21] by obtaining 20-second video clips of five different sites by a device with a × 5 objective lens.
The cells were gated on previously established bitmaps based on the forward and side scatter characteristics of each population.
The high ranking CpG sites from four candidate genes, characterized as either A) agnostic based on p-value alone (BEX2 and cXorf23; Additional file 1: Table S3) or B) biologically prioritized based on a previously established association with BPA (HOXA10 and DTL; Additional file 1: Table S6) were validated by quantitative bisulfite pyrosequencing (Additional file 1: Table S2).
The methodology is based on a previously established strategy that relies on airborne LiDAR sampling of forests found across a range of ecological conditions, but limited to one island [23].
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based on previously learned
based on previously introduced
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