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Doses of 15 μmol/L genistein and 3 Gy radiation were selected based on previous dose titration experiments [ 24].
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The dose of caspase inhibitors was based on previous dose-response studies [66], [67].
Based on previous dose-response investigations, the mycobacterial antigens were all used at 1 µg/ml.
Based on previous dose-response experiments, 150 μg/kg liposomal siRNA every 72 hours effectively downregulates gene expression in vivo.
The chemotherapy doses are based on previous dose-finding studies in The Netherlands Cancer Institute [ 12, 13] (see discussion).
These optimal LPA and S1P concentrations were determined based on previous dose-response curves in hNP cells (Hurst et al., 2008b).
FF and/or VI were dosed once daily at the doses of 100 μg and 25 μg, respectively, based on previous dose-ranging studies across a range of asthma severities 10– 10.
We chose a 10 ng/ml dose of IL-7 for further experiments, based on previous dose-response studies conducted in other cell types that found that 10 ng/ml was required for stimulation of mononuclear and T-cell proliferation [ 11, 13] and TNF-α production [ 12].
The procedure concerning curative OAT included a nomogram for adjusting doses of fluindione and warfarin based on previous doses and the INR (see Tables 2 and 3).
The doses used in the current study were based on previous experiments and dose-dependent effects observed in our laboratory.
NTG dose was 10 mg/kg based on previous studies that this dose reliably produced alterations in allodynia 2 h after administration [15, 16].
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