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Based on previous association studies, for the DRD2 TaqI A, individuals with at least one A1 allele were designated as A1+ and those who were homozygous for the A2 allele were designated A1-.
These genes were then correlated based on previous association between genes or proteins and known functional roles of genes.
5' UTR, exon, exon-intron boundary, 3'UTR and minor allele frequency (MAF, >0.05) reported in dbSNP or based on previous association studies.
Based on previous association studies of the DRD2 TaqI A polymorphism, individuals with at least one A1 allele were designated as A1+ and those who were homozygous for the A2 allele were designated A1-.
For the TRF2 association diagram, two subsections were illustrated: (i) a connected diagram that shows identified proteins that can be traced back to TRF2 by some degree of separation (Figure 2) and (ii) an unconnected diagram that represents identified protein networks/complexes that do not connect back to the bait protein based on previous association data (Figure 3).
Polymorphisms were chosen based on previous association with ADHD in either clinical or QTL studies (Table 1).
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The SNPs analyzed in this study have been selected based on previous associations and tagging properties, and are mostly contained within NPSR1 intronic sequences.
Ten SNPs were selected based on previous associations, reported in GWAS, with either melanocytic nevi or melanoma risk or both.
Polymorphisms were selected from the literature (based on previous associations (Additional file 1) or functional effects) and dbSNP (Additional file 2).
Given a chromosomal region linked to an inherited disease by analysis of the genomes of patients and healthy controls, a novel candidate gene in that region might be identified based on previous associations.
All samples were genotyped on the Metabochip, a custom genotyping array containing 196,725 SNPs, the majority of which were chosen based on previous associations with metabolic, cardiovascular, and anthropometric traits, as well as to fine map the regions around these previously associated variants [ 19].
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based on previous associations
based on previous weight
based on previous report
based on previous research
based on political association
based on multiple association
based on previous consumption
based on previous achievement
based on social association
based on genetic association
based on relational association
based on strong association
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based on predictive association
based on previous client
based on possible association
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