Previous research developed mathematical models in an attempt to analytically minimize cutting losses based on preliminary engineering designs, but little insight has been provided on how to integrate minimization of cutting losses and engineering design into an integrated optimization problem, let alone considering minimizing total steel rebar installation cost as a parallel objective.
The concentrations of agonists included were chosen based on preliminary experiments designed to identify concentrations of agonists that induced low (10 30%) and intermediate (30 50%) levels of P-selectin expression in healthy controls.
Based on preliminary results, the design was expanded in a couple of stages to ensure that the relevant parameter domains were adequately spanned.
Based on preliminary experiments, we designed and applied the following treatments in analyses of thermotolerance and gene expression: 'C', 3 h at 22°C; 'PT', 1 h at 36°C followed by 2 h at 22°C; 'HS39'HS39.59.5', 2 h at 22°C followed by 1 h at 39 or 39.5°C; 'PT+HS39'PT+HS39.59.5', 1 h at 36°C, followed by 1 h at 22°C, followed by 1 h at 39 or 39.5°C.
Based on preliminary experiments and CCRD design, the ranges of values of the operating conditions were selected: temperature 33 67 °C, feed flow-rate 46 114 L/h, and concentration 83 92 wt% for IPA and 93 98 wt% for Et in feed mixtures.
The lef-8 and E75 primer pairs were designed based on preliminary genome sequencing information of the virus and transcriptomic data available for C. crangon, respectively.
To develop these guidelines, we use population pharmacokinetic pharmacodynamic (PK PD) modeling and simulation by: (i) optimization of clinical trial designs based on preliminary data; (ii) development and internal validation of population PK PD models using sparse data; (iii) external validation using independent data; and (iv) prospective clinical evaluation.
Flanking primers were designed based on preliminary data of the whole genome sequence of F. noatunensis ssp.
Moreover, the concentrator designs are often based on preliminary geological data, and are therefore subject to uncertainty.
