Sentence examples for based on predicted epitopes from inspiring English sources
A multi-epitope construct was designed based on predicted epitopes which is 310 residues in length.
A multi-epitope vaccine was designed based on predicted epitopes which was 377 amino acid residues in length.
Mouse and human constructs were designed based on predicted T cell epitopes and MHC class I binders, which were then tandemly fused together.
T cell-dependent development of anti-Factor VIII (FVIII) antibodies that neutralize FVIII activity is a major obstacle to replacement therapy in hemophilia A. To create a less immunogenic therapeutic protein, recombinant FVIII can be modified to reduce HLA binding of epitopes based on predicted anchoring residues.
A multi-epitope construction was designed based on the predicted epitopes which was 270 residues in length.
An extensive literature search for proteins from the well-studied Mtb organism gave experimental indication to validate our hypothesis that promising proteins for reverse vaccinology can be revealed based on the overall set of predicted epitopes.
PyMOL (Delano Scientific LLC, USA) was employed to depict predicted epitopes on each molecule (see Supplementary Table S3).
The method first divides antigen surfaces into overlapping patches based on both radius (R) and number (N), then predict epitopes based on Amino Acid Pairs (AAPs) from mimotopes and the surface patch.
(PDF 1198 kb) Additional file 7: Comparison of experimentally used and in silico designed spacers based on the polypeptide proposed by Ding et al. Red bars represent predicted epitopes and the intensity indicates overlapping epitopes at that position.
Based on the predicted localization of POM5 epitope in the area of 168 174 of mouse PrP, this is most likely the glycosylation linked to asparagine 181. Figure 5B shows a sequence alignment of PrPC molecules from different species on the position of the estimated POM5 epitope.
This peptide contained both B- and T-cell epitopes based on prediction models.
