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It is recommended that all donors enrolled in the BOLD study be ventilated with 10 cc/kg of tidal volume based on predicted body weight to minimize ventilator-associated lung injury [21].
Although we would have preferred to use the NHLBI ARDsNet protective ventilatory strategy of 6 ml/kg of tidal volume based on predicted body weight [28], this preference had to be weighed against the CTDN priority for optimizing inflation volumes to demonstrate good lung function to promote lung utilization for transplantation.
Anaesthetic concentrations were based on predicted body weight.
Explicit instructions for identification of appropriate patients and for setting tidal volumes and positive end-expiratory pressure (PEEP) based on predicted body weight and oxygenation targets has the potential to prevent errors in which healthcare providers order inappropriate ventilator settings.
It is recommended that all donors enrolled in the BOLD study be ventilated with 10 cc/kg of tidal volume based on predicted body weight to minimize ventilator-associated lung injury [ 21].
Although we would have preferred to use the NHLBI ARDsNet protective ventilatory strategy of 6 ml/kg of tidal volume based on predicted body weight [ 28], this preference had to be weighed against the CTDN priority for optimizing inflation volumes to demonstrate good lung function to promote lung utilization for transplantation.
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Sample size calculations were based on predicted HbA1c and body weight after trial completion.
It is important to highlight, particularly in obese patients, that the desired VT should be calculated based on the predicted body weight and not on the actual body weight because the increased thoracic appearance is due to excessive adipose tissue but not a greater intrathoracic (lung) volume.
Because it is well established that patients' lungs are well correlated with their height [3], accurate tidal volume setting should be based on ideal or predicted body weight that is functions of height and gender, rather than on actual weight to avoid acquired acute lung injury and ARDS [4 6] and to improve outcome [7].
Indexing to estimated body surface area, again based on real or predicted body weight, provided no advantage.
The bone marrow transplantation laboratory then determines the dose of cells to be administered based on the patient's predicted body weight [4].
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based on predicted target
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